Professor Anne Lingford-Hughes is Professor of Addiction Biology at Imperial College and Head, Centre for Psychiatry. She is also a Consultant Psychiatrist in addictions at Central North West London NHS Foundation Trust. She graduated in medicine from Oxford University, completed her PhD at Cambridge University, and trained in psychiatry at The Bethlem and Maudsley Hospitals and Institute of Psychiatry. She is currently Chair of the Academic Faculty of Royal College of Psychiatrists and Professional Liaison Officer, British Neuroscience Association. She also leads an MRC funded PhD programme to produce future clinical addiction academic leaders – MARC.
Research interests :
- Using neuroimaging, pharmacological and behavioural challenges to characterize the neurobiology of addiction to alcohol, opiate, cocaine, gambling and nicotine
- Assessing brain responses during methadone detoxification and early abstinence and their modulation by NK1 antagonism
- Assessing brain responses to baclofen in alcoholism.
1. Limbrick-Oldfield EH, Mick I, Cocks RE, Flechais RSA, Turton S, Lingford-Hughes A, Bowden-Jones H, Clark L. Neural and neurocognitive markers of vulnerability to gambling disorder: a study of unaffected siblings. Neuropsychopharmacology. 2019 Oct Epub
2. Durant CF, Paterson LM, Turton S, Wilson SJ, Myers JFM, Muthukumaraswamy S, Venkataraman A, Mick I, Paterson S, Jones T, Nahar LK, Cordero RE, Nutt DJ, Lingford-Hughes A. Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures. Front Psychiatry. 2018 Dec 14;9:664.
3. Turton S, Myers JF, Mick I, Colasanti A, Venkataraman A, Durant C, Waldman A, Brailsford A, Parkin MC, Dawe G, Rabiner EA, Gunn RN, Lightman SL, Nutt DJ, Lingford-Hughes A. Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals. Mol Psychiatry. 2018 Jun 25.
4. Quelch DR, Mick I, McGonigle J, Ramos AC, Flechais RS, Bolstridge M, Rabiner E, Wall MB, Newbould RD, Steiniger-Brach B, van den Berg F, Boyce M, Østergaard Nilausen D, Breuning Sluth L, Meulien D, von der Goltz C, Nutt D, Lingford-Hughes A. (2017) Nalmefene Reduces Reward Anticipation in Alcohol Dependence: An Experimental Functional Magnetic Resonance Imaging Study. Biol Psychiatry. 81(11):941-948
5. Paterson LM, Flechais RS, Murphy A, Reed LJ, Abbott S, Boyapati V, Elliott R, Erritzoe D, Ersche KD, Faluyi Y, Faravelli L, Fernandez-Egea E, Kalk NJ, Kuchibatla SS, McGonigle J, Metastasio A, Mick I, Nestor L, Orban C, Passetti F, Rabiner EA, Smith DG, Suckling J, Tait R, Taylor EM, Waldman AD, Robbins TW, Deakin JW, Nutt DJ, Lingford-Hughes AR; ICCAM Platform. (2015) The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description. J Psychopharmacol. 29(9):943-60.